KMID : 1231220110020020089
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Journal of the Korean Society for Research on Nicotine and Tobacco 2011 Volume.2 No. 2 p.89 ~ p.96
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Smoking, C-reactive Protein, and the Metabolic Syndrome
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Jeon Hyo-Jin
Lee Dong-En Kwak Hye-Rim Yang Yun-Jun Lee Eon-Sook Lee Jun-Hyung Yoon Yeong-Sook
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Abstract
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Background: Smoking is a major risk factor of cardiovascular disease including metabolic syndrome (MS). The low grade systemic inflammation might play a role in the relationship between smoking and MS. This study was performed to identify the role of systemic inflammation using high-sensitivity c-reactive protein (hs-CRP) affecting the association of smoking status, daily smoking amount, and pack-years with MS.
Methods: We analyzed 2184 men 20 years of age or older who participated in the health screening program of university hospital in Gyeonggi-do, Korea.
Results: Current smokers showed significant higher level of hs-CRP (0.120¡¾0.065mg/dl) than never smokers (0.095¡¾0.062 mg/dl) (P£¼0.05). Daily smoking amount and total pack-years of smoking showed dose-dependent relationship with level of hs-CRP (P for trend £¼0.05). The adjusted odds ratio for the MS by daily smoking amount and total pack-years of smoking showed significant dose-dependent associations with MS (P for trend£¼0.001). Compared with never smoker, subjects who smoked ¡Ã30 cigarettes/day and ¡Ã30 pack-year smokers showed significantly increased odds of MS [adjusted OR 2.31 (1.53-3.50), 1.95 (1.36-2.77)]. This significant positive association between Daily smoking amount and total pack-years of smoking and MS was remained after adjustment for hs-CRP [2.22 (1.46-3.36), 1.87 (1.31-2.66), respectively)].
Conclusion: This study showed that smoking was significantly associated with MS, but this association was not explained by hs-CRP. Therefore, more research is needed to elucidate potential mechanism by which smoking increases the risk of MS.
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KEYWORD
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Tobacco smoking, Metabolic syndrome, C-reactive protein
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